Prognostic significance of chimeric fusion gene analysis in pediatric acute megakaryoblastic leukemia

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  • TAMEFUSA Kosuke
    Department of Pediatrics, Fukuyama City Hospital Department of Pediatrics, Okayama University Hospital
  • FUKUTAKE Koshiro
    Faculity of Medicine, Okayama University
  • ISHIDA Hisashi
    Department of Pediatric Hematology/Oncology, Okayama University Hospital
  • TAMURA Akihiro
    Department of Hematology/Oncology, Hyogo Prefectural Children’s Hospital
  • ENDO Mikiya
    Department of Pediatrics, Iwate Medical University
  • HAMAMOTO Kazuko
    Department of Pediatrics, Hiroshima Red Cross Hospital and Atomic-bomb Survivors Hospital
  • KOGA Yuhki
    Department of Pediatrics, Kyushu University Hospital
  • YAMADA Mutsuko
    Department of Pediatrics, Okayama University Hospital
  • KANAMITSU Kiichiro
    Department of Pediatrics, Okayama University Hospital
  • FUJIWARA Kaori
    Department of Pediatrics, Okayama University Hospital
  • WASHIO Kana
    Department of Pediatrics, Okayama University Hospital
  • SHIMADA Akira
    Department of Pediatric Hematology/Oncology, Okayama University Hospital

Bibliographic Information

Other Title
  • キメラスクリーニングによる小児急性巨核芽球性白血病の予後解析
  • 症例報告 第57回日本血液学会中国四国地方会 会長推薦演題 キメラスクリーニングによる小児急性巨核芽球性白血病の予後解析
  • ショウレイ ホウコク ダイ57カイ ニホン ケツエキ ガッカイ チュウゴク シコク チホウカイ カイチョウ スイセン エンダイ キメラスクリーニング ニ ヨル ショウニ キュウセイキョカク ガキュウセイ ハッケツビョウ ノ ヨゴ カイセキ

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<p>Acute megakaryoblastic leukemia in children without Down syndrome (non-DS AMKL) is considered to be a poor prognostic subtype in acute myeloid leukemia. Recently, some chimeric fusion genes were found in pediatric non-DS AMKL; therefore, we attempted to detect chimeric fusion genes RBM15-MKL1, CBFA2T3-GLIS2, and NUP98-KDM5A from 10 pediatric non-DS AMKL diagnostic samples using polymerase chain reaction and Sanger sequencing methods. Two samples were positive for RBM15-MKL1, four had CBFA2T3-GLIS2, and only one case had NUP98-KDM5A. Both RBM15-MKL1-positive patients showed long-term remission after chemotherapy. The eight RBM15-MKL1-negative patients received hematopoietic stem cell transplantation (HSCT). In four CBFA2T3-GLIS2-positive patients, three had HSCT without complete remission and two of themdied. Additional treatment stratification depending on chimeric fusion genes and development of new therapeutic drugs are required for non-DS AMKL.</p>

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 60 (2), 99-105, 2019

    The Japanese Society of Hematology

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