Enhancement of Synaptic Transmission of Sub-threshold Current Stimulus with High Rate Pulsatile Electric Stimuli in a Recurrent Neuron Model

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  • MORI Ryosuke
    Department of Electrical Engineering, Kanto Gakuin University
  • MINO Hiroyuki
    Department of Electrical Engineering, Kanto Gakuin University

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  • 高レートパルス状電気刺激による循環型ニューロンモデルでの閾値未満シナプス電流刺激の伝達強化
  • コウレートパルスジョウ デンキ シゲキ ニ ヨル ジュンカンガタ ニューロンモデル デ ノ イキチ ミマン シナプス デンリュウ シゲキ ノ デンタツ キョウカ

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<p>Stochastic resonance (SR) is known as a phenomenon whereby detection of sub-threshold low level stimuli is improved by the addition of random noise at specific noise amplitudes in nonlinear threshold systems such as a neuron. In recent years, we reported observation of a SR-like phenomenon by the addition of periodic pulsatile electric stimuli at a specific pulse rate. The objective of this study was to investigate whether periodic pulsatile electric stimuli at a specific pulse rate enhance synaptic transmission of sub-threshold stimuli and induce periodic spike firings in a recurrent neuron model of four pyramidal neurons with a sub-threshold synaptic current. Computer simulations showed that while no spike firing was observed at lower pulse rates, periodic spike firings were observed as the pulse rate increased. However, with further increase in pulse rate, irregular spike firings were observed due to occurrence of unwanted spikes. Computer simulations also showed that the mean inter-spike interval tended to decrease as pulse rate of electric stimuli increased at specific pulse amplitudes. These results indicated that a pulse rate-dependent resonance phenomenon was present in a recurrent neuron model with sub-threshold synaptic current, and that desirable spike firing rate or mean inter-spike interval could be determined by setting appropriate pulse rate of the electric stimuli.</p>

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