分子動力学シミュレーションによる不凍タンパク質RiAFPの氷の結晶成長に及ぼす影響の解析
書誌事項
- タイトル別名
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- Molecular Dynamics studies on the effects of Antifreezing Protein from Rhagium inquisitor (RiAFP) on Ice Growth
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説明
<p>Antifreezing nature of an antifreezing proteins (AFPs) from Rhagium inquisitor, RiAFP, was assessed by means of molecular dynamics (MD) simulations of RiAFP adsorbing ice surface in water below melting temperature to investigate how RiAFP affects the way of ice growth. We found that the ice growth toward the horizontal direction is accelerated, while that toward the vertical direction is suppressed due to the RiAFP binding on the nascent ice surface. We also showed that a mutant of RiAFP, where all Thr are replaced by Gly, resulted in loss of antifreezing effects due to weaker binding to the ice surface though the structure of the mutant is stable in aqueous solution at the room temperature.</p>
収録刊行物
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- Journal of Computer Chemistry, Japan
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Journal of Computer Chemistry, Japan 17 (5), 222-224, 2018
日本コンピュータ化学会
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詳細情報 詳細情報について
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- CRID
- 1390845713058974592
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- NII論文ID
- 130007618075
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- NII書誌ID
- AA11657986
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- ISSN
- 13473824
- 13471767
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- HANDLE
- 2241/00157878
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- 本文言語コード
- ja
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- 資料種別
- journal article
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- データソース種別
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- JaLC
- IRDB
- Crossref
- CiNii Articles
- OpenAIRE
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- 抄録ライセンスフラグ
- 使用不可