書誌事項
- タイトル別名
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- Study on Adaptation of the Standard Formulation to the Direct Compression Method (1)—Comparison to Direct Compression Lactose and Wet Granulation Method—
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説明
<p>We defined the lactose/corn starch in a 7/3 mixture with 20 w/w% binder as the standard formulation for the dry compression method and investigated the adaptation of this formulation for the direct compression method. Powdered crystalline lactose monohydrate, which is generally used as an additive for solid dosage forms, and three kinds of direct compression lactose with differing physicochemical properties were used as lactose. Microcrystalline cellulose (PH-101) or low-substituted hydroxypropylcellulose (LH-21) were used as binder. Consequently, tablets that had sufficient hardness of 40 N or higher as well as disintegration ability within one minute were obtained using this formulation without using direct compression lactose. Moreover, these tablets had excellent characteristics compared with tablets obtained by the standard formulation for the wet granulation method. As for the binder, the hardness of tablets containing the microcrystalline cellulose was higher than that of the tablets containing the low-substitute hydroxypropylcellulose. However, the difference was not significant, and there were no differences in the disintegration time between those two tablets.</p>
収録刊行物
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- 薬剤学
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薬剤学 65 (6), 390-400, 2005
公益社団法人 日本薬剤学会
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キーワード
詳細情報 詳細情報について
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- CRID
- 1390845713063536384
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- NII論文ID
- 10020420920
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- NII書誌ID
- AN00266708
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- ISSN
- 21883149
- 03727629
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可