Nickel-Catalyzed Hydrocyanation of Allenes and Its Application

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  • Arai Shigeru
    Graduate School of Pharmaceutical Sciences, Chiba University

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Abstract

<p>Cyano (CN) groups are equivalent to carbonyl as well as amino- and hydroxymethyl groups. Therefore, their catalytic introduction under metal catalysis is an important issue in synthetic organic chemistry. Ni-catalyzed hydrocyanation is one of the most well-investigated, powerful tools for installing a CN group. However, it is still difficult to control chemo- and regioselectivity. In this review, the author uses allenes to enable regio-, stereo-, and face-selective transformations to natural product synthesis and axial chirality transfer.</p>

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