Electron Microscopy Observations of the Au Nanorods and Au Nanorod/SiO<sub>2</sub> Nanocapsules

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  • NAKASHIMA Kouichi
    Department of Materials Science and Engineering, Ibaraki University
  • INOSE Tomoya
    Department of Materials Science and Engineering, Ibaraki University
  • OIKAWA Takahiro
    Department of Nano-Medical Science, Graduate School of Medicine, Tohoku University Department of Gastroenterological Surgery, Graduate School of Medicine, Tohoku University
  • TOKUNAGA Masayuki
    Department of Medical Physics, Graduate School of Medicine, Tohoku University
  • HATOYAMA Keiichiro
    Department of Nano-Medical Science, Graduate School of Medicine, Tohoku University Department of Gastroenterological Surgery, Graduate School of Medicine, Tohoku University
  • KAKIHANA Masato
    Institute of Multidisciplinary Research for Advanced Materials, Tohoku University
  • GONDA Kohsuke
    Department of Nano-Medical Science, Graduate School of Medicine, Tohoku University Department of Gastroenterological Surgery, Graduate School of Medicine, Tohoku University
  • KOBAYASHI Yoshio
    Department of Materials Science and Engineering, Ibaraki University

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  • Electron Microscopy Observations of the Au Nanorods and Au Nanorod/SiO₂ Nanocapsules

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<p>An in-depth analysis of the morphology of Au nanorod/SiO2 nanocapsules was performed by scanning transmission electron microscopy (STEM) imaging, secondary electron (SE) imaging, bright-field (BF) imaging, and high-angle annular dark-field (HAADF) imaging. These detailed analyses and high X-ray computerized tomography (CT) values provided key information for the administration of Au nanorod/SiO2 nanocapsules into the blood of mice. Au, which is a heavy element, exhibits a high X-ray CT value. STEM images were recorded to clearly analyze the morphology of the Au nanorods and Au nanorod/SiO2 nanocapsules. The results obtained from SE images, BF images, and HAADF images revealed that Au nanorods are covered by SiO2 and that Au nanorod/SiO2 nanocapsules are highly dispersed. Furthermore, 3D tomography reconstruction was performed by using STEM observation. Three-dimensional tomography reconstruction revealed a spatial structure and provided highly reliable information on the Au nanorod/SiO2 nanocapsules developed in this study.</p>

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