A safety-focused method of oral immunotherapy (OIT) for food allergy

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  • Takaoka Yuri
    Department of Pediatrics, Osaka Habikino medical center

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  • 食物アレルギーの経口免疫療法 (OIT) の安全性をふまえた方法と管理

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<p> According to the Food Allergy Clinical Practice Guideline 2016, the definition of oral immunotherapy (OIT) is as follows : “The antigen is orally administered under the guidance of a doctor after confirming the threshold levels in the oral food challenge test in cases where the achievement of natural tolerance is delayed. It is defined as a therapy that is aimed at acquiring tolerance ultimately after increasing the threshold levels”. OIT has received attention for its potential as an effective treatment of food allergy.</p><p> While OIT is an effective treatment for increasing the threshold, it may possibly cause a severe reaction ; hence, adequate safety measures are necessary while administering OIT. However, since there is not enough evidence regarding the superiority or inferiority of the OIT method itself, there is no unified safety protocol developed yet, and research should be conducted to clarify this.</p><p> Therefore, in this report, we describe a method of OIT that incorporates feasible safety, evaluation of the patient’s risk in advance, and setup necessary to minimize the risk of OIT protocols.</p>

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