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Mutant Frequency is not Increased in Mice Orally Exposed to Sodium Dichromate
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- Aoki Yasunobu
- National Institute for Environmental Studies, Center for Health and Environmental Risk Research, Tsukuba, Japan
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- Matsumoto Michiyo
- National Institute for Environmental Studies, Center for Health and Environmental Risk Research, Tsukuba, Japan
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- Matsumoto Michi
- National Institute for Environmental Studies, Center for Health and Environmental Risk Research, Tsukuba, Japan
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- Masumura Kenichi
- National Institute of Health Sciences, Division of Genetics and Mutagenesis, Kawasaki, Japan
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- Nohmi Takehiko
- National Institute of Health Sciences, Division of Genetics and Mutagenesis, Kawasaki, Japan
Bibliographic Information
- Published
- 2019
- Resource Type
- journal article
- DOI
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- 10.14252/foodsafetyfscj.2018014
- Publisher
- Food Safety Commission, Cabinet Office, Government of Japan
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Description
<p>The in vivo mutagenicity of hexavalent chromium in the small intestine, the target organ of tumorgenicity, was examined by means of a transgenic mouse gene mutation assay. Sodium dichromate dihydrate was administered orally in drinking water to male gpt delta mice at a dose of 85.7 or 257.4 mg/L for 28 days or at a dose of 8.6, 28.6 or 85.7 mg/L for 90 days. No significant increase in gpt mutant frequency relative to that in control mice was observed in the small intestine in either the 28- or 90-day study, whereas 28-day oral administration of potassium bromate, a positive control substance, increased mutant frequency.</p>
Journal
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- Food Safety
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Food Safety 7 (1), 2-10, 2019
Food Safety Commission, Cabinet Office, Government of Japan
