Vitamin a Deficiency Impairs Host Resistance to Listeria Monocytogenes Infection Through Excessive Apoptosis of macrophages

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  • Tanaka Nahoko
    Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine
  • Hiraga Hiroto
    Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine
  • Sakuraba Hirotake
    Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine
  • Murai Yasuhisa
    Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine
  • Maeda Takato
    Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine
  • Watanabe Rina
    Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine
  • Ota Shinji
    Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine
  • Akemoto Yui
    Department of Pathology and Laboratory Medicine, Hirosaki University Graduate School of Medicine
  • Hasui Keisuke
    Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine
  • Yoshida Shukuko
    Shibata Irika Co., Ltd., Hirosaki, Japan
  • Asano Krisana
    Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine
  • Nakane Akio
    Department of Microbiology and Immunology, Hirosaki University Graduate School of Medicine
  • Fukuda Shinsaku
    Department of Gastroenterology and Hematology, Hirosaki University Graduate School of Medicine

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タイトル別名
  • Vitamin A Deficiency Impairs Host Resistance to <i>Listeria Monocytogenes</i> Infection Through Excessive Apoptosis of Macrophages

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Vitamin A is essential for maintenance of homeostasis, and it also regulates various immune mechanisms.Listeria monocytogenes is a gram-positive bacillus that invades the cytoplasm of phagocytes and performs intracellular multiplication, and is often used as a tool for functional analysis of macrophages. In this study, we investigated the changes of macrophages under vitamin A deficiency（VAD）using L. monocytogenes. During L. monocytogenes infection, apoptosis was increased in CD11b-positive splenocytes of VAD mice compared with vitamin A sufficient（VAS） mice. A similar result was obtained with peritoneal exudate cells（PECs）. Significant increase of apoptosis due to the administration of Ro41-5253, an inhibitor of retinoic acid receptor, was also observed in the macrophage cell line RAW264.7. Furthermore, in VAD mice, the number of bacteria in the spleens and livers was significantly increased. These results suggest that excessive apoptosis of macrophages occurs under VAD condition, leading to impaired host resistance to L. monocytogenes. Taken together, vitamin A contributes to the maintenance of homeostasis by regulating macrophage functions, indicating the importance of vitamin A supplementation.

収録刊行物

  • 弘前医学

    弘前医学 69 (1-4), 163-171, 2019-03-15

    弘前大学大学院医学研究科・弘前医学会

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