Clinical outcome and analysis of sperm cryopreservation for male cancer patients

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  • 当院でのがん患者の妊孕性温存を目的とした精子凍結保存法の実態と同法を用いた不妊治療成績の検討
  • トウ イン デ ノ ガン カンジャ ノ ニンヨウセイ オンゾン オ モクテキ ト シタ セイシ トウケツ ホゾンホウ ノ ジッタイ ト ドウホウ オ モチイタ フニン チリョウ セイセキ ノ ケントウ

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Abstract

<p>The purpose of sperm cryopreservation in cancer patients is to preserve fertility and improve quality of life. We report our experience with sperm cryopreservation from 2001. During the study period (Jan 2001-Feb 2018), a total of 369 patients underwent private sperm banking at our hospital. We analyzed the type of cancer, timing of sperm cryopreservation, sperm quality, and clinical outcomes of assisted reproductive technology. Among all patients, there were 217 testicular tumor patients (58.8%) and 89 hematological malignancy patients (24.1%). Chemotherapy was administered to almost 54% of non-urological patients, but to only 7.1% of urological patients. All patients with previous chemotherapy had below-normal sperm concentration and motility. Forty-one patients utilized their specimens for reproductive purposes. Intracytoplasmic sperm injection using frozen sperm was performed in 40 cases, of which 29 resulted in successful birth. The fertilization rate of this procedure was 79.4%, and the clinical pregnancy rate per embryo transfer was 47.6%. This analysis indicates that sperm cryopreservation is an effective method of fertility preservation. It is important to inform young cancer patients of sperm cryopreservation options promptly after diagnosis. To improve awareness toward oncofertility, we must understand and inform patients of the significance of fertility preservation using sperm cryopreservation. [Adv Obstet Gynecol, 71(1) : 1-8, 2019 (H31.2)]</p>

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