Prognostic Significance of Intramural Metastasis in Patients with Esophageal Squamous Cell Carcinoma

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  • Okamura Akihiko
    Esophageal Surgery Division, Department of Gastroenterological Surgery, Gastroenterology Center, The Cancer Institute Hospital of Japanese Foundation for Cancer Research
  • Watanabe Masayuki
    Esophageal Surgery Division, Department of Gastroenterological Surgery, Gastroenterology Center, The Cancer Institute Hospital of Japanese Foundation for Cancer Research
  • Kozuki Ryotaro
    Esophageal Surgery Division, Department of Gastroenterological Surgery, Gastroenterology Center, The Cancer Institute Hospital of Japanese Foundation for Cancer Research
  • Takahashi Keita
    Esophageal Surgery Division, Department of Gastroenterological Surgery, Gastroenterology Center, The Cancer Institute Hospital of Japanese Foundation for Cancer Research
  • Toihata Tasuku
    Esophageal Surgery Division, Department of Gastroenterological Surgery, Gastroenterology Center, The Cancer Institute Hospital of Japanese Foundation for Cancer Research
  • Imamura Yu
    Esophageal Surgery Division, Department of Gastroenterological Surgery, Gastroenterology Center, The Cancer Institute Hospital of Japanese Foundation for Cancer Research
  • Mine Shinji
    Esophageal Surgery Division, Department of Gastroenterological Surgery, Gastroenterology Center, The Cancer Institute Hospital of Japanese Foundation for Cancer Research

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Other Title
  • 食道扁平上皮癌における壁内転移の意義
  • ショクドウ ヘンペイ ジョウヒ ガン ニ オケル カベ ナイ テンイ ノ イギ

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Abstract

<p>Intramural metastasis (IM) from esophageal squamous cell carcinoma (ESCC) is sometimes found. The aim of this study was to clarify the specific characteristics and survival impact of IM in patients with ESCC. Among 840 patients who underwent surgery for ESCC, 44 (5.2%) had IM. Patients with IM had significantly more advanced tumors compared with those without. In addition, the curative resection rate was lower in patients with IM (p<0.01). Overall survival (OS) and disease-specific survival (DSS) of patients with IM were significantly worse than those without IM (both p<0.01). In multivariate analysis, the presence of IM was one of the independent risk factors for poor OS and DSS (both p<0.01). To improve outcomes in such cases, multimodal treatment with strong antitumor activity should be considered.</p>

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