Epidemiological Report : Genome-Based Epidemiological Analysis of 13 Acinetobacter Strains Isolated from Blood Cultures of Hospitalized Patients from a University Hospital in Japan

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  • Oinuma Ken-Ichi
    Department of Bacteriology, Osaka City University Graduate School of Medicine Research Center for Infectious Disease Sciences, Osaka City University Graduate School of Medicine
  • Suzuki Masato
    Antimicrobial Resistance Research Center, National Institute of Infectious Diseases
  • Nakaie Kiyotaka
    Department of Infection Control and Prevention, Osaka City University Hospital Department of Infection Control Science, Osaka City University Graduate School of Medicine
  • Sato Kanako
    Department of Bacteriology, Osaka City University Graduate School of Medicine Department of Respiratory Medicine, Osaka City University Graduate School of Medicine
  • Saeki Kozo
    Department of Bacteriology, Osaka City University Graduate School of Medicine Department of Medical Technology, Morinomiya University of Medical Sciences
  • Sakiyama Arata
    Department of Bacteriology, Osaka City University Graduate School of Medicine
  • Takizawa Etsuko
    Department of Laboratory Medicine, Osaka City University Hospital
  • Niki Makoto
    Department of Bacteriology, Osaka City University Graduate School of Medicine Department of Laboratory Medicine, Osaka City University Hospital
  • Niki Mamiko
    Department of Bacteriology, Osaka City University Graduate School of Medicine Research Center for Infectious Disease Sciences, Osaka City University Graduate School of Medicine
  • Yamada Koichi
    Research Center for Infectious Disease Sciences, Osaka City University Graduate School of Medicine Department of Infection Control Science, Osaka City University Graduate School of Medicine
  • Shibayama Keigo
    Department of Bacteriology II, National Institute of Infectious Diseases
  • Kakeya Hiroshi
    Research Center for Infectious Disease Sciences, Osaka City University Graduate School of Medicine Department of Infection Control Science, Osaka City University Graduate School of Medicine
  • Kaneko Yukihiro
    Department of Bacteriology, Osaka City University Graduate School of Medicine Research Center for Infectious Disease Sciences, Osaka City University Graduate School of Medicine

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タイトル別名
  • Genome-Based Epidemiological Analysis of 13 <i>Acinetobacter</i> Strains Isolated from Blood Cultures of Hospitalized Patients from a University Hospital in Japan
  • Genome-based epidemiological analysis of 13 Acinetobacter strains isolated from blood cultures of hospitalized patients from a university hospital in Japan

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<p>The genus Acinetobacter comprises many species that can cause infectious diseases. Despite their importance as nosocomial pathogens, the clinical distributions of individual species or clones are not well understood. In this study, we aimed to characterize 13 Acinetobacter strains isolated from blood cultures from Osaka City University Hospital. We conducted whole-genome sequencing to reveal their genetic background. We also performed PCR-based open reading frame typing (POT) and compared the results with those of multilocus sequence typing (MLST) to confirm its reliability as a genotyping method. Although biochemical analysis suggested that most isolates were A. baumannii, genomic analysis revealed that the collection of Acinetobacter isolates comprised six different species, with non-baumannii Acinetobacter species representing the majority. All strains possessed an inherent ADC-type β-lactamase gene, whereas the distribution of OXA-type enzymes was limited to A. baumannii, A. pittii, and A. colistiniresistens. While MLST properly discriminated four A. baumannii strains as different clones, POT failed to distinguish three of the four A. baumannii strains from each other, highlighting a potential pitfall that may be encountered when applying POT to non-epidemiological A. baumannii strains.</p>

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