Comparisons of levodopa plasma concentration in continuous LCIG infusion and neurological findings

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  • Yabe Hayato
    Department of Neurology, Saiseikai Matsuyama Hospital
  • Ootsubo Haruki
    Department of Neurology and Clinical Pharmacology, Ehime University School of Medicine
  • Kubo Madoka
    Department of Neurology and Clinical Pharmacology, Ehime University School of Medicine
  • Miyaue Noriyuki
    Department of Neurology, Saiseikai Matsuyama Hospital
  • Tada Satoshi
    Department of Neurology and Clinical Pharmacology, Ehime University School of Medicine
  • Ando Rina
    Department of Neurology and Clinical Pharmacology, Ehime University School of Medicine
  • Nagai Masahiro
    Department of Neurology and Clinical Pharmacology, Ehime University School of Medicine
  • Nomoto Masahiro
    Department of Neurology and Clinical Pharmacology, Ehime University School of Medicine

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Other Title
  • L–ドパ持続経腸療法における血中濃度の検討―効果と課題について

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<p>Introduction :</p><p>Levodopa carbidopa intestinal gel (LCIG) was approved for advanced Parkinson's disease (PD).</p><p>We performed LCIG therapy in patients with advanced PD.</p><p>The effect and problem including the plasma levodopa level in continues LCIG infusion were studied.</p><p></p><p>Method :</p><p>Six PD patients treated with LCIG were included in this study. Pharmacokinetics, efficacy and adverse events were assessed.</p><p></p><p>Results :</p><p>Compared with baseline, LCIG decreased off time. The degree of fluctuation of levodopa plasma concentrations were small while continues LCIG infusion.</p><p>In spite of the constant plasma levodopa, one of the 6 cases presented motor fluctuations.</p><p>Intersubject variability of levodopa plasma concentrations were present. And the plasma levodopa level of the same patient fluctuated among the days.</p><p>Therefore, there was no strict correlation between LCIG dosing rate and plasma concentration of levodopa, when compared with intravenous levodopa infusion.</p><p>The dosing rate of levodopa was adjusted according to the plasma levodopa concentration in one case.</p><p></p><p>Conclusion :</p><p>The monitoring of the levodopa plasma cncentrations is useful for determination of dosing rate.</p>

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