Itch in Atopic Dermatitis-the Role of Skin as Sensory Receptor

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  • Kamo Atsuko
    順天堂大学大学院医学研究科環境医学研究所
  • Tominaga Mitsutoshi
    Department of Neurobiology, Physiology and Behavior, University of California, Davis
  • Takamori Kenji
    順天堂大学大学院医学研究科環境医学研究所 順天堂大学医学部附属浦安病院院長

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Other Title
  • アトピー性皮膚炎と皮膚感覚受容器
  • アトピーセイ ヒフエン ト ヒフ カンカク ジュヨウキ

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Abstract

<p>Itch is an essential symptom of atopic dermatitis (AD) and constitutes one of the major diagnostic criteria of AD. Compared with healthy individuals, the skin of atopic patients is characterized by specific features that result in a lower itch threshold and hypersensitivity to certain non-specific triggers. Thus, itch in AD has a chronic and refractory character and can sometimes be very resistant to treatment. The itch-scratch vicious circle is frequently observed in patients with AD, being an important factor in the maintenance of AD symptoms. Here, we focus on the role of skin as a sensory receptor and overview the regulation of itch shown in AD.</p>

Journal

  • KENBIKYO

    KENBIKYO 46 (4), 233-237, 2011-12-30

    The Japanese Society of Microscopy

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