The Effects of Tea Catechins on Bone Metabolism

DOI Open Access
  • Tominari Tsukasa
    Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology
  • Ichimaru Ryota
    Cooperative Major in Advanced Health Science, Tokyo University of Agriculture and Technology
  • Matsumoto Chiho
    Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology
  • Hirata Michiko
    Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology
  • Miyaura Chisato
    Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology Cooperative Major in Advanced Health Science, Tokyo University of Agriculture and Technology
  • Inada Masaki
    Department of Biotechnology and Life Science, Tokyo University of Agriculture and Technology Cooperative Major in Advanced Health Science, Tokyo University of Agriculture and Technology

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  • 茶カテキンの骨代謝調節作用

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Abstract

 Catechins, such as catechin, epicatechin (EC), epigallocatechin (EGC) and epigallocatechin gallate (EGCG), are polyphenols contained in green tea. Catechins exhibits various biological functions including antioxidative activities; however, the effects of catechins on bone metabolism are still unclear.<br>  We have reported that EGCG and methylated EGCG (EGCG3’’Me), methylated derivative of EGCG, exerted the bone protective effects against an experimental periodontitis model.<br>  Both EGCG and EGCG3’’Me inhibited osteoclast differentiation and bone resorption. In osteoblasts, EGCG and EGCG3’’Me directly attenuated IκB kinase (IKK) activity, leading to the inhibition of osteoclast differentiation through the decreased production of prostaglandin (PG) E2 and receptor activator of NF-κB ligand (RANKL).<br>  We further showed that EGCG and EGCG3’’Me suppressed LPS-induced bone resorption of alveolar bone in an experimental periodontitis model.<br>  The intake of EGCG has also shown to inhibit the estrogen deficiency-induced bone loss in ovariectomized animal model. Since it is the important issues to prevent the bone loss in super-aging society, catechins are the candidates for the prevention of bone-related diseases. This review described the effects of catechins on bone diseases including periodontitis and postmenopausal osteoporosis.

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