Isolated Prolonged Activated Partial Thromboplastin Time （APTT） Without Bleeding Tendency in Three Cats

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  • 出血傾向を伴わずに活性化部分トロンボプラスチン時間（APTT）が単独延長した猫の3例

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<p>This study examined whether asymptomatic blood coagulopathy occurs in cats. Citrated plasma samples were taken from 44 healthy cats brought to a primary animal hospital for neutering or spaying. Using a dry-system coagulation analyzer (COAG2NV), we performed blood coagulation tests, including prothrombin time (PT), activated partial thromboplastin time (APTT), fibrinogen concentration (Fib), thrombotest (TB), and hepaplastin test (HPT), on the samples. Reference intervals (RI) were defined as the mean ± 2 standard deviations of the collected values. The RI for PT was 9.1 - 10.7 sec, for TB was 18.7 - 25.5 sec, and for HPT was 16.1 - 24.0 sec. Samples with high fibrinogen concentration were excluded using the iterative truncation method with correction. Consequently, the RI for Fib of 42 healthy cats was 66.8 - 203.1 mg/dl. Two of the samples with extremely prolonged APTT were excluded by the same method, generating an RI of 21.6 - 58.8 sec for the APTT of 42 healthy cats. In addition to the 2 excluded samples, 1 incorporated sample (69.0 sec) fell outside of the RI for APTT, and all 3 samples had decreased activation of Factor XII. These 3 cats (6.8% = 3/44) were asymptomatic and lacked bleeding tendencies. We conclude that asymptomatic blood coagulopathy is highly prevalent in cats. </p>

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