Re-construction of Living System from Single Cells : Development of On-chip Cellomics Measurement Technology(Current Topics)

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  • 生命システムの構成的再構築の試み : オンチップ・セロミクス計測技術の開発(最近の研究から)
  • 生命システムの構成的再構築の試み--オンチップ・セロミクス計測技術の開発
  • セイメイ システム ノ コウセイテキ サイコウチク ノ ココロミ オンチップ セロミクス ケイソク ギジュツ ノ カイハツ

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Abstract

We have developed on-chip cellomics measurement technology to understand the meaning of 'geometric' system of cells (emphasis on spatial aspects; spatial pattern-dependent community effect). Using our re-constructive approach and technology, cells' interaction and community sizes are fully controlled on the chip with arranging cells one by one. In this review, we explain two topics of our results; the importance of stability of beating intervals to determine which cell rules the synchronized rhythm when two indepent cells made contact, and the contribution of community effect for improvement of beating interval stability.

Journal

  • Butsuri

    Butsuri 65 (3), 181-186, 2010-03-05

    The Physical Society of Japan

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