Cleavage Signal Induced by the Mitotic Spindle; Insights from Live Cell Imaging

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  • Kamijo Keiju
    東北大学大学院医学系研究科・細胞組織学分野

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Other Title
  • 細胞分裂面決定機構と分裂シグナルのライブイメージング
  • 最近の研究と技術 細胞分裂面決定機構と分裂シグナルのライブイメージング
  • サイキン ノ ケンキュウ ト ギジュツ サイボウ ブンレツメン ケッテイ キコウ ト ブンレツ シグナル ノ ライブイメージング

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Abstract

<p>During cytokinesis, the final step of cell cycle, actin and myosin fibers assemble at the equatorial cell cortex and form the contractile ring. The motor activity of myosin II is believed to generate constriction force that cleaves a parent cell into two daughter cells. Anaphase microtubules provide the specification signal for the contractile ring, yet the nature of the signal remains unclear. In this review, I discuss how microtubules specify the contractile ring. I show that the small GTPase Rho and a complex of Rho regulators (ECT2 RhoGEF, MgcRacGAP, MKLP1 kinesin) act as a cleavage signal that specifies the contractile ring. I also discuss the visualization of the cleavage signal generated by anaphase microtubule, using live cell imaging techniques.</p>

Journal

  • KENBIKYO

    KENBIKYO 44 (2), 135-138, 2009-06-30

    The Japanese Society of Microscopy

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