CD20-negative diffuse large B-cell lymphoma complicated by rheumatoid arthritis

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  • YOSHINO Teruhiko
    Department of Hematology, National Hospital Organization Nagasaki Medical Center
  • MAKIYAMA Junya
    Department of Hematology, National Hospital Organization Nagasaki Medical Center Clinical Research Center, National Hospital Organization Nagasaki Medical Center
  • IMAIZUMI Yoshitaka
    Department of Hematology, Nagasaki University Hospital
  • MATSUO Emi
    Department of Hematology, Japan Community Health care Organization Isahaya General Hospital
  • KITANOSONO Hideaki
    Department of Hematology, National Hospital Organization Nagasaki Medical Center
  • NAKASHIMA Jun
    Department of Hematology, National Hospital Organization Nagasaki Medical Center
  • KATO Takeharu
    Department of Hematology, National Hospital Organization Nagasaki Medical Center
  • MIYOSHI Hiroaki
    Department of Pathology, Kurume University School of Medicine
  • OHSHIMA Koichi
    Department of Pathology, Kurume University School of Medicine
  • YOSHIDA Shinichiro
    Department of Hematology, National Hospital Organization Nagasaki Medical Center
  • MIYAZAKI Yasushi
    Department of Hematology, Atomic Bomb Disease and Hibakusha Medicine Unit, Atomic Bomb Disease Institute, Nagasaki University

Bibliographic Information

Other Title
  • 関節リウマチを合併したCD20陰性びまん性大細胞型B細胞リンパ腫・非特異型
  • 症例報告 関節リウマチを合併したCD20陰性びまん性大細胞型B細胞リンパ腫・非特異型
  • ショウレイ ホウコク カンセツ リウマチ オ ガッペイ シタ CD20 インセイビマンセイ ダイ サイボウガタ Bサイボウ リンパシュ ・ ヒトクイガタ

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Description

<p>CD20 antigen is an important marker for diagnosis of B-cell neoplasms that is highly expressed on the surface of neoplastic B lymphocytes. Patients with rheumatoid arthritis (RA) have an increased risk of developing malignant lymphoma, of which diffuse large B-cell lymphoma (DLBCL) is the most common type. We report an unusual case of CD20-negative DLBCL complicated by rheumatoid arthritis. An 81-year old female presented with a left-sided cervical tumor, enlarged tonsil, and polyarticular pain. Pathological findings of the left tonsil showed proliferation of large atypical cells with irregular shaped nuclei. Most large cells were negative for CD3 and CD20. Additionally, these cells were positive for CD79a, BCL2, and MUM1, and negative for CD10, CD138, BCL6, PAX5, EBV-ISH, HHV8, and ALK.. Therefore, she was diagnosed with CD20-negative DLBCL complicated with RA and received dose-modified CHOP that achieved partial remission. Because CD20-negative DLBCL is rare, the identification of the clinicopathological features of this disease is urgently required.</p>

Journal

  • Rinsho Ketsueki

    Rinsho Ketsueki 61 (1), 33-38, 2020

    The Japanese Society of Hematology

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