INFLUENCE OF STELLATE GANGLION BLOCK ON THE DEVELOPMENT OF ALLERGIC RHINITIS

KAWASHIMA Yoshimi, OTAKI Amane, ASANO Kazuhito

doi:10.14930/jshowaunivsoc.79.654

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Other Title

アレルギー性鼻炎の発症に及ぼす星状神経節ブロックの効果
アレルギー性鼻炎の発症に及ぼす星状神経節ブロックの効果 : ラットを用いての作用機序の実験的解析
アレルギーセイビエンノハッショウニオヨボスホシジョウシンケイセツブロックノコウカ : ラットオモチイテノサヨウキジョノジッケンテキカイセキ
―ラットを用いての作用機序の実験的解析―

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Abstract

Allergic rhinitis（AR）is an allergic inflammation in the nasal mucosa. It is known that approximately 400 million people suffer from AR throughout the world. Numerous effective therapeutic options are available, including topical application of steroids, oral administration of antihistamine and immunotherapy. However, as these therapeutic options have several adverse effects, further research on the medical management of AR is needed. Stellate ganglion block（SGB）is frequently used for the treatment of AR with successful results. However, the precise mechanisms by which SGB can favorably modify the clinical conditions of AR are not well understood. The present experiments were designed to examine the possible therapeutic mechanisms of SGB on the development of AR using experimental AR model rats. SD male rats, 5 weeks of age, were sensitized with toluene 2,4-diisocyanate（TDI）by intranasal instillation of a 10％ TDI once a day for 5 consecutive days. This sensitization procedure was repeated after a 2-day interval. After five days of sensitization, sensitized rats were subjected to SGB and challenged intranasally with TDI. SGB significantly inhibited the development of nasal allergy-like symptoms（such as sneezing and nasal rubbing movements）and also decreased levels of both substance P（SP）and calcitonin gene-related peptide（CGRP）in nasal lavage fluids, which are induced by intranasal challenge with TDI. These results strongly suggest that SGB could favorably modify the clinical conditions of AR through the suppression of the appearance of SP and CGRP in nasal walls.

Journal

Journal of The Showa University Society

Journal of The Showa University Society 79 (5), 654-660, 2019

The Showa University Society

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