書誌事項
- タイトル別名
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- Yokukansan and keishito ameliorate ASD-like sociability deficits in ovariectomized mice
説明
<p>Autism spectrum disorder (ASD) is a neurodevelopmental disorder with core symptoms of sociability deficit. We focus on allopregnanolone (ALLO) which is a neurosteroidal positive modulator of the GABAA receptor. Our previous findings showed that post-weaning social isolation rearing (SI) of male mice induces ASD-like sociability deficits, and these abnormalities are in part due to SI-induced decreases in ALLO contents in the brain. It is also demonstrated that yokukansan (YKS) and keishito (KST), traditional herbal medicines, improved sociability deficits in SI mice. Moreover, we reported that dissection of ovary (OVX) of female mice also induced ASD-like sociability deficits. This study investigated the effects of YKS and KST on the ASD-like behavioral abnormalities of OVX mice. The ovariectomy was conducted on 6-week-old mice. The administration of YKS and KST was started 1 week after surgical operation. After finishing behavioral tests, the ALLO contents in cortex were measured by ELISA. YKS and KST improved the ASD-like sociability deficits induced by OVX without restoring brain ALLO levels, similar to the results of SI mice. These results suggest that YKS and KST are effective for ASD treatment. Currently, we are analyzing the mechanism of YKS and KST for improving sociability deficits.</p>
収録刊行物
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- 日本薬理学会年会要旨集
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日本薬理学会年会要旨集 93 (0), 3-P-285-, 2020
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390846609812732032
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- NII論文ID
- 130007811764
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- ISSN
- 24354953
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
- OpenAIRE
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- 抄録ライセンスフラグ
- 使用不可