Stimulatory effect of the extract of fruit body of <i>Cordyceps</i><i> militaris</i> on the secretion of testosterone in rats
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- Miyagawa Mayuko
- Dept. Endocrine Pharmacol., Tokyo Univ. Pharm. Life Sci.
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- Kusama Kazuya
- Dept. Endocrine Pharmacol., Tokyo Univ. Pharm. Life Sci.
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- Miyaoka Hiroaki
- Dept. Biomolecular Organic Chem., Tokyo Univ. Pharm. Life Sci.
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- Ota Koichiro
- Dept. Biomolecular Organic Chem., Tokyo Univ. Pharm. Life Sci.
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- Nakasone Toyokazu
- Okinawa UKAMI Sericulture Co.,Ltd.
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- Okamatsu Shigemi
- Okinawa UKAMI Sericulture Co.,Ltd.
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- Tamura Kazuhiro
- Dept. Endocrine Pharmacol., Tokyo Univ. Pharm. Life Sci.
Bibliographic Information
- Other Title
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- 沖縄産エリ蚕蛹を宿主とする冬虫夏草子実体抽出成分のテストステロン分泌亢進作用
Description
<p>Testosterone, primarily produced in Leydig cells, is essential for a variety of systemic functions, and deficiency of this hormone results in late-onset hypogonadism (LOH) in climacteric male. In the present study, we prepared the extract of fruit body of Cordyceps militaris parasitized in Samia Cynthia ricini, designated as Ryukyu-Kasou (RK), as a novel candidate for ameliorating male menopause symptom. To explore the effect of RK on LOH, we have investigated the testosterone dynamics using castrated rats and isolated primary rat Leydig cells. Testosterone propionate (TP) and the extract of RK were administered to castrated rats for 12 days. The serum levels of testosterone and dihydrotestosterone (DHT) were maintained highly in the RK-treated group, compared with control. In addition, RK reduced TP-stimulated increases in the weight of prostate gland. When cultured testicular cells were stimulated with luteinizing hormone (LH) or dibutyryl-cyclic AMP (cAMP) in the presence or absence of RK, LH- or cAMP-induced testosterone secretion in the media was enhanced by the presence of RK with no changes in the mRNA expression of steroidogenic enzymes. Thus, RK-derived unknown compounds suppressed the testosterone catabolism in vivo and stimulated testosterone secretion in vitro, suggesting the possibility of RK for improving LOH.</p>
Journal
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- Proceedings for Annual Meeting of The Japanese Pharmacological Society
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Proceedings for Annual Meeting of The Japanese Pharmacological Society 93 (0), 1-SS-15-, 2020
Japanese Pharmacological Society
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Keywords
Details 詳細情報について
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- CRID
- 1390846609813461632
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- NII Article ID
- 130007811402
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- ISSN
- 24354953
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed