書誌事項
- タイトル別名
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- α7 Nicotinic acetylcholine (ACh) receptors (α7 nAChRs) expressed on antigen-presenting cells (APCs) suppress the differentiation of CD4<sup>+</sup> T cells.
抄録
<p>All the immune cells such as T cells, macrophages and dendritic cells (DCs), have ACh-synthesizing ability and express α7 nAChRs involved in regulation of proliferation, and synthesis of antigen-specific antibodies and proinflammatory cytokines. We investigated role of α7 nAChRs on APCs in regulation of CD4+ T cell differentiation. Spleen cells, including naïve CD4+ T cells and APCs (macrophages and DCs), were isolated from ovalbumin (OVA)-specific TCR transgenic DO11.10 mice, and cultured with OVA in the presence of GTS-21, an α7 nAChR agonist. GTS-21 suppressed the OVA-activated CD4+ T cell differentiation into regulatory T cells (Tregs), Th1, Th2 and Th17 cells. GTS-21 inhibited the production of Th cytokines (IFN-γ, IL-4 and IL-17). GTS‑21 inhibited differentiation into Tregs of OVA-induced CD4+ T cells co-cultured with APCs from the wild-type (WT) mice but did not affect differentiation of T cells co-cultured with APCs from α7 nAChR-deficient mice. These results suggest a critical role of α7 nAChRs on APCs in regulation of CD4+ T cell differentiation, and that α7 nAChR agonists and antagonists could be potentially useful agents for immune response modulation and enhancement.</p>
収録刊行物
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- 日本薬理学会年会要旨集
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日本薬理学会年会要旨集 92 (0), 2-P-088-, 2019
公益社団法人 日本薬理学会
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詳細情報 詳細情報について
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- CRID
- 1390846609814495744
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- NII論文ID
- 130007813089
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- ISSN
- 24354953
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- 本文言語コード
- ja
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- データソース種別
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- JaLC
- Crossref
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可