Probiotics/prebiotics have the potential to prevent the onset of allergy

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  • Ito Komei
    Department of General Pediatrics, Aichi Children's Health and Medical Center

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  • プロ・プレバイオティクスによるアレルギー予防は可能か
  • Pro：アレルギー予防は可能である

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Abstract

<p>Many immunological studies have revealed a critical role of the gut microflora in the maintenance of systematic immunity. Probiotics are defined as "live microorganisms that, when administered in adequate amounts, confer a health benefit on the host". Most corresponding microorganisms are of the Bifidobacterium and Lactobacillus species. Probiotic bacteria may have a direct ability to alter the human immune system, because not only live bacteria, but also dead bacteria, can effectively promote the acquisition of oral tolerance.</p><p>Recent studies have focused on the effects of short chain fatty acids produced by the gut microflora on the development of regulatory T cells and oral tolerance. The dominant microbiota is classified into Clostridium species, which might have different activity from classical probiotic bacteria.</p><p>Prebiotics is defined as "a substrate that is selectively utilized by host microorganisms conferring a health benefit". Typical materials include dietary fiber and non-digestible oligosaccharides. Some prebiotics increase the amount of short chain fatty acid in the gut, and are expected to be effective for preventing allergic diseases.</p>

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