Control of Osteogenic Differentiation Timing by Substrate Microtopography

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  • 表面微細構造を用いた骨芽細胞分化のタイミングの制御

Abstract

<p>Recent researches have shown that enhanced focal adhesion between cells and extracellular matrix (ECM) and intracellular actin polymerization can accelerate cellular functions like adhesion and differentiation. In this study, mesenchymal stem cells (MSCs) from Sprague Dawley (SD) rats were cultured on the substrates with surface topography, the groove patterns in micro scale, to verify the relationship between cell adhesion and differentiation. Impeded osteogenic differentiation was observed on cells cultured with micro-topographic substrates. This result may be caused by the decrease in focal adhesion. Through this study, it is expected that the technique to control bone regeneration by surface microtopography will be one more step closer.</p>

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