Tension-dependent Generation of Biochemical Signals on Actomyosin Fibers
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- HIRATA Hiroaki
- Mechanobiology Laboratory, Nagoya University Graduate School of Medicine
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- SOKABE Masahiro
- Mechanobiology Laboratory, Nagoya University Graduate School of Medicine
Bibliographic Information
- Other Title
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- アクトミオシンファイバーは張力依存的なシグナルを生成するプラットフォームとして機能する
- アクトミオシンファイバー ワ チョウリョク イソンテキ ナ シグナル オ セイセイ スル プラットフォーム ト シテ キノウ スル
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Abstract
<p>Actomyosin fibers in non-muscle cells generate contractile force to drive cell morphogenesis and migration. We find another role of these fibers as a platform for generating force-dependent biochemical signals. The MAP kinase ERK is activated on actomyosin fibers in response to tension developed in the fibers, which contributes to detecting anisotropy of cell deformation. The actin-binding, myosin-modulating protein calponin-3 is also phosphorylated on actomyosin fibers dependently on the fiber tension, which in turn increases myosin-based contractile force generation in the fibers. This positive feedback mechanism for tension development in actomyosin fibers enhances generation of force-dependent biochemical signals on the fibers.</p>
Journal
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- Seibutsu Butsuri
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Seibutsu Butsuri 60 (2), 089-093, 2020
The Biophysical Society of Japan General Incorporated Association
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Keywords
Details 詳細情報について
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- CRID
- 1390846609817503744
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- NII Article ID
- 130007818289
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- NII Book ID
- AN00129693
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- ISSN
- 13474219
- 05824052
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- NDL BIB ID
- 030415654
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- Text Lang
- ja
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- Data Source
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- JaLC
- NDL
- Crossref
- CiNii Articles
- KAKEN
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- Abstract License Flag
- Disallowed