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Recurrent episodes of hypothermia as a sequela of human herpesvirus 6 encephalitis following cord blood transplantation for acute myeloid leukemia
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- SAKOH Takashi
- Department of Hematology, Toranomon Hospital Kajigaya
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- TAYA Yuki
- Department of Hematology, Toranomon Hospital Kajigaya
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- HIRAYAMA Takehisa
- Department of Neurology, Mishuku Hospital
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- OBA Yuki
- Department of Diabetes and Metabolism, Toranomon Hospital Kajigaya
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- MITSUKI Takashi
- Department of Hematology, Toranomon Hospital Kajigaya
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- NISHIDA Aya
- Department of Hematology, Toranomon Hospital Kajigaya
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- ISHIWATA Kazuya
- Department of Hematology, Toranomon Hospital Kajigaya
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- WATANABE Chizuru
- Department of Diabetes and Metabolism, Toranomon Hospital Kajigaya
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- WAKE Atsushi
- Department of Hematology, Toranomon Hospital Kajigaya
Bibliographic Information
- Other Title
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- 臍帯血移植後に併発したHHV-6脳炎の後遺症として低体温発作を繰り返した急性骨髄性白血病
- 症例報告 第11回日本血液学会関東甲信越地方会 奨励賞 臍帯血移植後に併発したHHV-6脳炎の後遺症として低体温発作を繰り返した急性骨髄性白血病
- ショウレイ ホウコク ダイ11カイ ニホン ケツエキ ガッカイ カントウ コウシンエツチホウカイ ショウレイショウ サイタイケツ イショク ゴ ニ ヘイハツ シタ HHV-6 ノウエン ノ コウイショウ ト シテ テイタイオン ホッサ オ クリカエシタ キュウセイ コツズイセイ ハッケツビョウ
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Description
<p>A 46-year-old female patient underwent a cord blood transplantation (conditioning regimen: fludarabine/busulfan4/melphalan80; graft-versus-host disease (GVHD) prophylaxis: tacrolimus + mycophenolate mofetil) for acute myeloid leukemia (AML) with her 1st hematological complete response to induction therapy (idarubicin 3 days+cytarabine 7 days). She lost her consciousness due to human herpesvirus 6 (HHV-6) encephalitis on day 31, and therefore, we increased the foscarnet dosage (from 120 mg/kg to 180 mg/kg). Her consciousness level improved after treatment. However, 8 hours of sudden hypothermia occurred with hyperhidrosis, hypertension, and subsequent hyperglycemia on day 34. Her condition did not improve even after administration of anticonvulsant, steroid pulse, or intravenous immunoglobulin. A total of 75 attacks were observed until she was discharged on day 471. She has not shown chronic GVHD or relapsed AML since then. However, HHV-6 caused prolonged damage to her hypothalamus as observed through magnetic resonance imaging (MRI) and single-photon emission computed tomography (SPECT) using 99mTc ethyl cysteinate dimer even when the virus was not detected from her cerebrospinal fluid. This damage can be responsible for the hypothermia attacks. This is the first case report of prolonged series of hypothermia attacks for over a year as a sequela of HHV-6 encephalitis after a cord blood transplantation for AML.</p>
Journal
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- Rinsho Ketsueki
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Rinsho Ketsueki 61 (3), 274-279, 2020
The Japanese Society of Hematology
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Keywords
Details 詳細情報について
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- CRID
- 1390846609819108352
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- NII Article ID
- 130007821406
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- NII Book ID
- AN00252940
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- ISSN
- 18820824
- 04851439
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- NDL BIB ID
- 030383373
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- PubMed
- 32224590
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- Text Lang
- ja
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- Article Type
- journal article
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- Data Source
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- JaLC
- NDL Search
- PubMed
- CiNii Articles
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- Abstract License Flag
- Disallowed