中心静脈栄養用輸液に混注されたインスリンの含量変化に関する検討

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書誌事項

タイトル別名
  • Stability of Insulin in Total Parenteral Nutrition Solutions
  • チュウシン ジョウミャク エイヨウヨウユエキ ニ コンチュウ サレタ インスリン ノ ガンリョウ ヘンカ ニ カンスル ケントウ

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説明

<p>Elneopa NF No. 1 and No. 2 infusions are complete parenteral nutrition solutions packaged as four-chambered bags. They have been used for home parenteral nutrition, with insulin injected into the bags for patients whose blood glucose becomes elevated. In this study, the stability of insulin in No. 1 and No. 2 bags was investigated. The quantity of insulin in Elneopa NF No. 2 was significantly lower than that in Elneopa NF No. 1. When insulin was injected into the upper chamber of either product, decreases in insulin levels were not observed. In contrast, the levels of insulin injected into the lower chamber of both products significantly decreased, with a larger difference in Elneopa NF No. 2. As the amino acid content is different between No. 1 and No. 2, amino acids may be considered a potential cause for the degradation of insulin in the bags. In addition, decreases in insulin levels were observed as the solutions passed through infusion sets just after flushing began, with both Elneopa NF No. 1 and No. 2. In conclusion, the concentration of insulin injected into the Elneopa infusion bags decreases, especially in No. 2 bags, and insulin is absorbed by the infusion sets.</p>

収録刊行物

  • 薬学雑誌

    薬学雑誌 140 (4), 577-584, 2020-04-01

    公益社団法人 日本薬学会

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