Neuropathology of autonomic nervous system in Lewy body diseases

DOI
  • Yoshida Mari
    Institute for Medical Science of Aging, Aichi Medical University

Bibliographic Information

Other Title
  • レビー小体病の自律神経障害と病理

Description

<p>The histological hallmark of Lewy body disease (LBD), which encompasses Parkinson’s disease, Parkinson’s disease with dementia, dementia with Lewy body disease, and pure autonomic failure with Lewy bodies, is neuronal α-synuclein aggregates called LBs and Lewy neurites. Neuronal α-synuclein aggregates are distributed throughout the nervous system, including not only the central nervous system (CNS) including sustantia nigra, locus ceruleus, dorsal motor nucleus of the vagus, intermediolateral nucleus of thoracic cord and hypothalamus, but also sympathetic ganglia, enteric nervous system, cardiac and pelvic plexuses, submandibular gland, adrenal medulla and skin. Involvement of central and peripheral autonomic nervous system is characteristic feature of LBD. Non-motor symptoms of LBD closely related to the pathological α-synuclein aggregates in central and peripheral autonomic nervous system. The long duration of pure autonomic failure with Lewy bodies may suggest that development of α-synuclein aggregates from peripheral autonomic nervous system to CNS is not always the same as those among LBD.</p>

Journal

Keywords

Details 詳細情報について

  • CRID
    1390846609821709568
  • NII Article ID
    130007827414
  • DOI
    10.32272/ans.57.1_010
  • ISSN
    24347035
    02889250
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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