A case of immune checkpoint inhibitor-related colitis induced by pembrolizumab for advanced lung cancer

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  • 肺癌に対するペムブロリズマブ使用中に 免疫関連有害事象による大腸炎を発症した一例

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A 62-year-old man with advanced lung cancer developed watery diarrhea and hematochezia 26 weeks after the first administration of pembrolizumab. Colonoscopy showed colitis mimicking ulcerative colitis; however, unlike previous reports about immune checkpoint inhibitor-related colitis, our patient had discontinuous lesions. The pathologic findings showed crypt abscesses and advanced inflammatory cell infiltration. We diagnosed the patient with an immune-related adverse event induced by pembrolizumab. After steroid therapy, the clinical manifestations and endoscopic findings were markedly improved. There are few reports involving the endoscopic features of immune checkpoint inhibitor-related colitis, and we believe that this may be a valuable case for further discussion of the endoscopic features.

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