Osteoimmunology : Bidirectional dialogue and inevitable union of the fields of bone and immunity
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- TAKAYANAGI Hiroshi
- Department of Immunology, Graduate School of Medicine and Faculty of Medicine, The University of Tokyo
書誌事項
- タイトル別名
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- Osteoimmunology — Bidirectional dialogue and inevitable union of the fields of bone and immunity —
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説明
<p>Bone is a critically important part of the skeletal system that is essential for body support and locomotion. The immune system protects against pathogens and is active in host defense. These two seemingly distinct systems in fact interact with each other, share molecules and create a collaborative regulatory system called the “osteoimmune system”. The most representative osteoimmune molecule is receptor activator of NF-κB ligand (RANKL), which plays multiple roles in the osteoimmune system under both physiological and pathological conditions such as rheumatoid arthritis and cancer metastasis to bone. Based on accumulating evidence for such mutual dependence, it is concluded that the relationship between bone and the immune system did not develop by accident but as a necessary consequence of evolution. Here I describe the history of and recent advances in osteoimmunology, providing a perspective in the contexts of both science and medicine.</p>
収録刊行物
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- Proceedings of the Japan Academy. Ser. B: Physical and Biological Sciences
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Proceedings of the Japan Academy. Ser. B: Physical and Biological Sciences 96 (4), 159-169, 2020-04-10
日本学士院
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詳細情報 詳細情報について
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- CRID
- 1390846609823726080
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- NII論文ID
- 130007830083
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- NII書誌ID
- AA00785485
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- ISSN
- 13492896
- 03862208
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- NDL書誌ID
- 030375888
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- PubMed
- 32281551
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 使用不可