Pathological study of tubular aggregates occurring spontaneously in the skeletal muscles of non-obese diabetic/Cg-Prkdc[scid]Il2rgt[m1sug]/ShiJic (NOG) mice
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- Igura Saori
- Gotemba Laboratory, BoZo Research Center Inc., 1284 Kamado, Gotemba, Shizuoka 412-0039, Japan
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- Nagatani Mariko
- Gotemba Laboratory, BoZo Research Center Inc., 1284 Kamado, Gotemba, Shizuoka 412-0039, Japan
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- Kasahara Kenichiro
- Tsukuba Research Institute, BoZo Research Center Inc., 8 Okubo, Tsukuba, Ibaraki 300-2611, Japan
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- Andoh Rie
- Gotemba Laboratory, BoZo Research Center Inc., 1284 Kamado, Gotemba, Shizuoka 412-0039, Japan
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- Fukunaga Yachiyo
- Tsukuba Research Institute, BoZo Research Center Inc., 8 Okubo, Tsukuba, Ibaraki 300-2611, Japan
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- Hashiguchi Osamu
- Gotemba Laboratory, BoZo Research Center Inc., 1284 Kamado, Gotemba, Shizuoka 412-0039, Japan
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- Okazaki Shuzo
- Gotemba Laboratory, BoZo Research Center Inc., 1284 Kamado, Gotemba, Shizuoka 412-0039, Japan
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- Yamaguchi Yuko
- Gotemba Laboratory, BoZo Research Center Inc., 1284 Kamado, Gotemba, Shizuoka 412-0039, Japan
書誌事項
- タイトル別名
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- Pathological study of tubular aggregates occurring spontaneously in the skeletal muscles of non-obese diabetic/Cg<i>-Prkdc<sup>scid</sup>Il2rgt<sup>m1sug</sup></i>/ShiJic (NOG) mice
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<p> To examine the biological and morphological features of tubular aggregates (TAs) in the skeletal muscles of non-obese diabetic/Cg-PrkdcscidIl2rgtm1Sug/ShiJic (NOG) mice, 73 male and 72 female specific-pathogen-free NOG mice were examined at 7, 18, 22, 26, and 52 weeks of age. TAs were observed as intracytoplasmic eosinophilic materials of the femoral muscles in males at 18, 22, 26, and 52 weeks of age and in females at 52 weeks of age; gender-related differences were noted in the onset time and lesion degree. Intracytoplasmic materials were positive for Gomori’s trichrome stain. Electron microscopy revealed that TAs were composed of an accumulation of dilated sarcoplasmic reticulum. In addition, TAs were observed in the femoral and gastrocnemius muscles, but not in the soleus and diaphragm muscles, suggesting that TAs are present in fast muscle fibers. The morphology of TAs and the type of myofibers involved, as well as the gender difference in NOG mice were essentially the same as those of TAs observed in C57BL/6J and MRL+/+ mice.</p>
収録刊行物
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- Journal of Toxicologic Pathology
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Journal of Toxicologic Pathology 33 (2), 115-119, 2020
日本毒性病理学会
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詳細情報 詳細情報について
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- CRID
- 1390848250106584192
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- NII論文ID
- 130007835674
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- NII書誌ID
- AN10232280
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- ISSN
- 1881915X
- 09149198
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- NDL書誌ID
- 030447880
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
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- 使用不可