Development of DDS for mRNA therapeutics: Polyplex nanomicelle

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  • Itaka Keiji
    Department of Biofunction Research, Institute of Biomaterials and Bioengineering, Tokyo Medical and Dental University（TMDU）

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Other Title
  • mRNA医薬に利用されるキャリア開発：ナノミセル型キャリア
  • mRNA イヤク ニ リヨウ サレル キャリア カイハツ : ナノミセルガタ キャリア

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Description

mRNA therapeutics is defined as a new type of nucleic acid medicine by direct administration of synthesized mRNA into the body for therapeutic and prophylactic purposes. Since mRNA is extremely unstable outside the cells, DDS plays a crucial role for delivering the mRNA into the target cells in the body. LNPs have been most frequently used for mRNA delivery, however, it is still difficult to target various tissues and organs other than the liver. We are developing an original DDS, polyplex nanomicelle, which is advantageous in its excellent capacity of tissue penetration after local administration, as well as the low toxicity due to the biodegradability of the nanomicelle. In this article, I would like to introduce the system of polyplex nanomicelle, and the recent studies using the nanomicelles for administering mRNA therapeutics for disease treatment.

Journal

  • Drug Delivery System

    Drug Delivery System 35 (1), 27-34, 2020-01-25

    THE JAPAN SOCIETY OF DRUG DELIVERY SYSTEM

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