Constituents of the Fruiting Body of Poisonous Mushroom <i>Omphalotus japonicus</i>

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  • Aoki Satoki
    The United Graduate School of Agricultural Science, Iwate University
  • Aboshi Takako
    The United Graduate School of Agricultural Science, Iwate University Faculty of Agriculture, Yamagata University
  • Shiono Yoshihito
    The United Graduate School of Agricultural Science, Iwate University Faculty of Agriculture, Yamagata University
  • Kimura Ken-ichi
    The United Graduate School of Agricultural Science, Iwate University
  • Murata Toshihiro
    Department of Pharmacognosy, Tohoku Medical and Pharmaceutical University
  • Arai Daisuke
    Field Science Center, Faculty of Agriculture, Yamagata University
  • Iizuka Yoshiaki
    Field Science Center, Faculty of Agriculture, Yamagata University
  • Murayama Tetsuya
    The United Graduate School of Agricultural Science, Iwate University Faculty of Agriculture, Yamagata University

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  • Constituents of the Fruiting Body of Poisonous Mushroom Omphalotus japonicus

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Abstract

<p>Six new sesquiterpenes, tsukiyols A–C, neoilludin C, and 4-O-methylneoilludins A and B, were isolated from the fruiting body of Omphalotus japonicus (Kawam.) Kirchm. & O. K. Mill. Additionally, six known compounds, illudin S, neoilludins A–B, 5-hydroxydichomitol, ergosterolperoxide, and 3β,5α,9α-trihydroxyergosta-7,22-diene-6-one, were also obtained. Their chemical structures were determined with MS, IR, and NMR spectra and the absolute configurations of neoilludins A–C, 4-O-methylneoilludins A, and B were determined with electronic circular dichroism (ECD). Illudin S and 3β,5α,9α-trihydroxyergosta-7,22-diene-6-one showed cytotoxicity against human acute promyelocytic leukemia HL60 cells. Illudin S, 4-O-methylneoilludin A, B, and tsukiyol C showed growth-restoring activity against mutant yeast via Ca2+-signal transduction.</p>

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