Constituents of the Fruiting Body of Poisonous Mushroom Omphalotus japonicus
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- Aoki Satoki
- The United Graduate School of Agricultural Science, Iwate University
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- Aboshi Takako
- The United Graduate School of Agricultural Science, Iwate University Faculty of Agriculture, Yamagata University
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- Shiono Yoshihito
- The United Graduate School of Agricultural Science, Iwate University Faculty of Agriculture, Yamagata University
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- Kimura Ken-ichi
- The United Graduate School of Agricultural Science, Iwate University
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- Murata Toshihiro
- Department of Pharmacognosy, Tohoku Medical and Pharmaceutical University
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- Arai Daisuke
- Field Science Center, Faculty of Agriculture, Yamagata University
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- Iizuka Yoshiaki
- Field Science Center, Faculty of Agriculture, Yamagata University
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- Murayama Tetsuya
- The United Graduate School of Agricultural Science, Iwate University Faculty of Agriculture, Yamagata University
書誌事項
- タイトル別名
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- Constituents of the Fruiting Body of Poisonous Mushroom <i>Omphalotus japonicus</i>
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説明
<p>Six new sesquiterpenes, tsukiyols A–C, neoilludin C, and 4-O-methylneoilludins A and B, were isolated from the fruiting body of Omphalotus japonicus (Kawam.) Kirchm. & O. K. Mill. Additionally, six known compounds, illudin S, neoilludins A–B, 5-hydroxydichomitol, ergosterolperoxide, and 3β,5α,9α-trihydroxyergosta-7,22-diene-6-one, were also obtained. Their chemical structures were determined with MS, IR, and NMR spectra and the absolute configurations of neoilludins A–C, 4-O-methylneoilludins A, and B were determined with electronic circular dichroism (ECD). Illudin S and 3β,5α,9α-trihydroxyergosta-7,22-diene-6-one showed cytotoxicity against human acute promyelocytic leukemia HL60 cells. Illudin S, 4-O-methylneoilludin A, B, and tsukiyol C showed growth-restoring activity against mutant yeast via Ca2+-signal transduction.</p>
収録刊行物
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- CHEMICAL & PHARMACEUTICAL BULLETIN
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CHEMICAL & PHARMACEUTICAL BULLETIN 68 (5), 436-442, 2020-05-01
公益社団法人 日本薬学会
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詳細情報 詳細情報について
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- CRID
- 1390848250108721024
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- NII論文ID
- 130007838762
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- NII書誌ID
- AA00602100
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- ISSN
- 13475223
- 00092363
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- NDL書誌ID
- 030401505
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- PubMed
- 32378541
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- 本文言語コード
- en
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- データソース種別
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- JaLC
- NDL
- Crossref
- PubMed
- CiNii Articles
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- 抄録ライセンスフラグ
- 使用不可