Patient risk factors for contact dermatitis development associated with 10% povidone-iodine

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  • 10%ポビドンヨードによる接触皮膚炎発生に関連する患者側のリスクファクター

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Povidone-iodine（PVP-I）is widely used for the disinfection of surgical sites. Although contact dermatitis（CD）due to PVP-I exposure has been studied, few reports have investigated the susceptibility factors in patients, which may be useful in simple screening. The present study compared the characteristics of patients in whom CD developed after PVP-I exposure and those in whom it did not and investigated the contributory factors. Based on data indicating that CD developed most often in the abdominal region of 6,583 patients who underwent surgery in the past two years, 355 patients whose their abdominal region was disinfected using PVP-1 during gastroenterological, gynecological, and transplantation surgery were enrolled. CD due to PVP-1 occurred in 39 patients（11%）. Binary logistic regression analysis was performed with four explanatory variables to determine the effect of CD occurrence. The results showed a correlation with a medical history of red flare due to alcoho（l odds ratio 5.94［95% confidence interval 1.52-23.09］, p < 0.05）and younger age（odds ratio 0.97［95% confidence interval 0.95-0.99］, p < 0.05）. In addition to implementing preventive measures for patients with risk factors detected in a preoperative interview, it is necessary to explain the risk of CD onset fully, obtain the patients’ consent in cases where the use of PVP-1 is unavoidable, and ensure sufficient observation after PVP-1 use.

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