Synthetic tissue engineering: Programming multicellular self-organization by designing customized cell-cell communication
-
- Toda Satoshi
- WPI Nano Life Science Institute, Kanazawa University
Search this article
Abstract
<p>Cells communicate with each other to organize multicellular collective systems and assemble complex, elaborate tissue structures by themselves during development. Despite intensive biological studies, what kind of cell-cell communication can sufficiently drive self-organization of specific tissue architectures remain unclear. Thanks to recent advances on genetic engineering technologies, synthetic biologists start to build customized cell-cell communication with user-defined signal input and gene expression output to program multicellular behaviors using mammalian systems. This review article introduces how we can design and engineer customized cell-cell communication to program synthetic self-organizing multicellular structures. Creating tissue formation processes with synthetic genetic programs will help understanding of fundamental principles of how genetic programs drive tissue self-organization and provide new capabilities on tissue engineering for cell-based regenerative therapy applications.</p>
Journal
-
- Biophysics and Physicobiology
-
Biophysics and Physicobiology 17 (0), 42-50, 2020
The Biophysical Society of Japan
- Tweet
Keywords
Details
-
- CRID
- 1390848250127812992
-
- NII Article ID
- 130007872428
-
- ISSN
- 21894779
-
- Text Lang
- en
-
- Data Source
-
- JaLC
- Crossref
- CiNii Articles
- KAKEN
-
- Abstract License Flag
- Disallowed