Evaluation of LUMIPULSE Presto IL-2R for soluble interleukin-2 receptor assay using LUMIPULSE L2400

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  • ISHIHARA Yuri
    Department of Clinical Laboratory, The University of Tokyo Hospital
  • SHIMOSAKA Hironori
    Department of Clinical Laboratory, The University of Tokyo Hospital
  • KURANO Makoto
    Department of Clinical Laboratory, The University of Tokyo Hospital Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo
  • SATO Tomoaki
    Department of Clinical Laboratory, The University of Tokyo Hospital
  • YATOMI Yutaka
    Department of Clinical Laboratory, The University of Tokyo Hospital Department of Clinical Laboratory Medicine, Graduate School of Medicine, The University of Tokyo
  • YASUDA Naomi
    Department of Clinical Laboratory, The University of Tokyo Hospital

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  • 免疫発光測定装置ルミパルスL2400を用いた可溶性インターロイキン-2レセプター測定試薬「ルミパルスプレストIL-2R」の基礎的性能評価

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<p>A soluble IL-2 receptor (sIL-2R), the circulating form of the IL-2 receptor, localizes on lymphoid and some cancer cells and is used widely as a biomarker for adult T-cell leukemia and non-Hodgkin lymphoma. In this study, we evaluated the performance of a chemical luminescence test reagent LUMIPULSE Presto IL-2R for the measurement of serum soluble IL-2 receptor using an automated immune chemiluminescent system LUMIPULSE L2400. The coefficients of variation for within-run and between-day reproducibilities ranged from 0.7% to 3.3%. Linearity was observed up to about 80,000 U/mL and the lower limit of detection was 2.79 U/mL. A good correlation was observed between Immulyze IL-2R and LUMIPULSE Presto IL-2R. In conclusion, the analytical performance of LUMIPULSE Presto IL-2R seemed acceptable for routine clinical laboratory tests.</p>

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