質量分析イメージングによる脳内モノアミン新規集積領域の同定

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  • Monoamine Mapping Using Mass Spectrometry Identified New Monoamine-rich Brain Nuclei
  • Symposium Review 質量分析イメージングによる脳内モノアミン新規集積領域の同定
  • Symposium Review シツリョウ ブンセキ イメージング ニ ヨル ノウナイ モノアミン シンキ シュウセキ リョウイキ ノ ドウテイ

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<p>Monoamine neurotransmitters are released by specialized neurons that regulate behavioral and cognitive functions. Although localization of monoaminergic neurons in the brain is well known, the distribution, concentration, and kinetics of monoamines remain unclear. We used mass spectrometry imaging (MSI) for simultaneous and quantitative imaging of endogenous monoamines to generate a murine brain atlas of serotonin (5-HT), dopamine (DA), and norepinephrine (NE) levels. We observed several nuclei rich in both 5-HT and a catecholamine (DA or NE). Additionally, we analyzed de novo monoamine synthesis or fluctuations in those nuclei. We propose that MSI is a useful tool to gain deeper understanding of associations among the localization, levels, and turnover of monoamines in different brain areas and their role in inducing behavioral changes.</p>

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  • 薬学雑誌

    薬学雑誌 140 (8), 979-983, 2020-08-01

    公益社団法人 日本薬学会

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