Development of the circulatory simulator for generating coronary hemodynamics with microcirculation

DOI
  • Ikehara Masaaki
    Cooperative Major in Advanced Biomedical Sciences, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan
  • Tsuboko Yusuke
    Waseda Reserch Institute for Science and Engineering, Waseda University, Tokyo, Japan
  • Matsubara Kaito
    Department of Modern Mechanical Engineering, Graduate School of Creative Science and Engeneering, Waseda University, Tokyo, Japan
  • Hattori Kaoru
    Cooperative Major in Advanced Biomedical Sciences, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan
  • Niinami Hiroshi
    Department of Cardiovascular Surgery, Tokyo Women's Medical University, Tokyo, Japan
  • Iwasaki Kiyotaka
    Cooperative Major in Advanced Biomedical Sciences, Graduate School of Advanced Science and Engineering, Waseda University, Tokyo, Japan

Bibliographic Information

Other Title
  • 左冠動脈前下行枝における心収縮に伴う冠微小循環変動を考慮した模擬循環回路の開発

Abstract

<p>The left anterior descending coronary artery (LAD) compliance and hemodynamics changes after coronary artery bypass grafting and percutaneous coronary intervention are unclear. We have been developing a mock circulatory system for reproducing coronary hemodynamics including microcirculation. In this study, we newly developed the controlling mechanism of coronary vascular resistance. The simulator consists of roller pomp, silicone-made LAD and microvascular model, check valve and compliance tubing. We developed the linear motion mechanism for the reproduction of fluctuation of peripheral coronary artery resistance following ventricular contraction. As a result of the synchronization of two types of actuators, we obtained physiological coronary hemodynamics with 130/80(96) mmHg of the pressure and 370 ml/min of the mean flow rate. The simulated pressure waveform showed characteristic bimodal and large diastolic peak. For more sophisticated simulation, we are preparing the reproduction of interaction between coronary and systemic circulation and improving the controlling mechanism of coronary vascular resistance.</p>

Journal

Details

  • CRID
    1390848250134428416
  • NII Article ID
    130007885079
  • DOI
    10.11239/jsmbe.annual58.391
  • ISSN
    18814379
    1347443X
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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