Study on the Influence of Relative Dose Intensity on Neo Adjuvant Chemotherapy and Adjuvant Chemotherapy for Breast Cancer
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- Iizuka Shunsuke
- Department of Pharmacy, Nihon University Hospital
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- Hayama Tatsuya
- Department of Pharmacy, Nihon University Itabashi Hospital
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- Kabaya Yumi
- Department of Pharmacy, Nihon University Itabashi Hospital
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- Tsutsumi Daisuke
- Pharmacist Education Center, Nihon University School of Pharmacy
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- Otsuka Hideki
- Department of Pharmacy, Tokyo Rinkai Hospital
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- Hayasaka Masatoshi
- Department of Pharmacy, Nihon University Itabashi Hospital
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- Sakurai Kenichi
- Department of Surgery, Division of Breast and Endocrine Surgery, Nihon University School of Medicine
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- Kikuchi Norikazu
- Department of Pharmacy, Nihon University Hospital
Bibliographic Information
- Other Title
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- 乳がん術前・術後補助化学療法に対する相対用量強度の影響に関する研究
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Abstract
<p>Maintaining Average Relative Dose Intensity (ARDI) in neo adjuvant chemotherapy and adjuvant chemotherapy in breast cancer leads to an improved therapeutic effect, but few patients have clear indicators.</p><p>In the study we report the effect of ARDI on the treatment effect in EC followed by weekly nab-PTX therapy. Our subjects were 48 patients with breast cancer who received EC followed by weekly nab-PTX therapy in neo adjuvant chemotherapy and adjuvant chemotherapy at Nihon University Itabashi Hospital between 2012 and 2017.</p><p>In the study we compared Disease-free survival (DFS) and adverse effect rates between the two groups of the ARDI ≥ 90% group and ARDI < 90% group.</p><p>The patients in the ARDI ≥ 90% group exhibited significant difference in 2 years DFS and 3 years DFS (2 years DFS: P = 0.0095, 3 years DFS: P = 0.0019) as compared to the ARDI < 90% group. In terms of the adverse effect incidence rate, pathological subtype by type DFS, there was no difference between the two groups. Maintaining ARDI at 90% or higher in this study leads to improvement of the therapeutic effect.</p>
Journal
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- Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences)
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Iryo Yakugaku (Japanese Journal of Pharmaceutical Health Care and Sciences) 45 (8), 485-490, 2019-08-10
Japanese Society of Pharmaceutical Health Care and Sciences
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Details 詳細情報について
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- CRID
- 1390848250135252864
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- NII Article ID
- 130007886517
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- ISSN
- 18821499
- 1346342X
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- Text Lang
- ja
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- Data Source
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- JaLC
- Crossref
- CiNii Articles
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- Abstract License Flag
- Disallowed