The Clinical Utility of Bilastine in Medication Status and Food Intake Status for Cutaneous Diseases Causing Itching

Ohshima Yuichiro, Ishiguro Akihiro, Shibata Tomoyuki, Uchida Rimi, Sato Yukina, Ando Yoriko, Takama Hiroyuki, Iwashita Nobuhiko, Yanagishita Takeshi, Takeo Tomohiro, Watanabe Daisuke

doi:10.11340/skinresearch.19.2_97

<p>Bilastine is administered under fasting conditions, which is uncommon for antihistamines. In a previous trial, fasting was defined as an interval of 1 hour or longer before meals and 2 hours or longer after meals. In this study, we investigated the effectiveness of bilastine by focusing on food intake (defined as“overeating”,“sufficient”,“moderate”, and“small amount”in descending order of intake), and the time interval between meals and medication. Daytime and nighttime itching assessed by the visual analog scale (VAS) improved significantly with“sufficient”and“moderate”food intakes. With “overeating” and “small amount”, almost all patients demonstrated improvement in itching VAS scores. With“overeating”, the time interval between meals and medication was greater than 150 minutes for all patients. Patients often had longer intervals between meal intake and medication as the meal size increased. Patients may have taken bilastine correctly on an empty stomach according to their food intake, which may have led to an improvement in the itching VAS. With“sufficient”meals, itching VAS scores improved as the interval between the meal and medication increased. On the other hand, with“moderate”meals, itching VAS scores improved regardless of the time interval. Our study revealed that larger meal volumes influence bilastine effects ; therefore, patients should be educated about the appropriate interval between meals and medication. Even if bilastine intake is timed according to the feeling of hunger, satisfactory effects may be observed when the amount of food intake is low. To increase the effectiveness of bilastine, it is important to clarify the appropriate time interval between food intake and medication according to the amount of food intake. Skin Research, 19 : 97-105, 2020 </p>

The Clinical Utility of Bilastine in Medication Status and Food Intake Status for Cutaneous Diseases Causing Itching

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