Cadmium-induced ABCB1 transporter expression in renal proximal tubular cells
-
- MORI Chikage
- Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University
-
- LEE Jin-Yong
- Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University
-
- TOKUMOTO Maki
- Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University
-
- SATOH Masahiko
- Laboratory of Pharmaceutical Health Sciences, School of Pharmacy, Aichi Gakuin University
Bibliographic Information
- Other Title
-
- カドミウムによる腎近位尿細管でのABCB1トランスポーターの発現誘導
Abstract
<p>Our previous study demonstrated that cadmium (Cd) triggers renal toxicity through the disruption of transporting system. In this study, we investigated the effect of Cd on the expression level of ABCB1 (ATP binding cassette transporter subfamily B member 1) transporter in HK-2 human proximal tubular cells. Treatment of HK-2 cells with Cd up to 40μM for 6 h showed little cytotoxicity; however, Cd treatment for 24 h showed approximately 80% cytotoxicity. ABCB1 mRNA level was significantly increased by Cd treatment for 6 h in HK-2 cells. The protein level of P-glycoprotein (ABCB1 gene product) was also increased by Cd treatment for 6 and 12 h. These results suggested that the increase in not only gene expression of ABCB1 but also protein level of P-glycoprotein by Cd may induce some abnormalities in transport system in the kidney.</p>
Journal
-
- Annual Meeting of the Japanese Society of Toxicology
-
Annual Meeting of the Japanese Society of Toxicology 47.1 (0), P-15S-, 2020
The Japanese Society of Toxicology
- Tweet
Details 詳細情報について
-
- CRID
- 1390848647544943744
-
- NII Article ID
- 130007898290
-
- Text Lang
- ja
-
- Data Source
-
- JaLC
- CiNii Articles
-
- Abstract License Flag
- Disallowed