Individual variations in expression of genes related to airway hyperresponsiveness in human trachea and lung
-
- KONDO Ayano
- Faculty of Pharmaceutical Sciences, Yokohama University of Pharmacy
-
- AKIYAMA Nozomi
- Faculty of Pharmaceutical Sciences, Yokohama University of Pharmacy
-
- CHO Natsumi
- Faculty of Pharmaceutical Sciences, Yokohama University of Pharmacy
-
- MIURA Nobuhiko
- Faculty of Pharmaceutical Sciences, Yokohama University of Pharmacy
-
- KAWAMURA Ikuo
- Faculty of Pharmaceutical Sciences, Yokohama University of Pharmacy
-
- MORI Yoko
- Faculty of Pharmacy, Meijo University
-
- NAGAI Moeko
- Faculty of Pharmacy, Meijo University
-
- ISOBE Takashi
- Faculty of Pharmaceutical Sciences, Yokohama University of Pharmacy
-
- OHKAWARA Susumu
- Faculty of Pharmaceutical Sciences, Yokohama University of Pharmacy
-
- HANIOKA Nobumitsu
- Faculty of Pharmaceutical Sciences, Yokohama University of Pharmacy
-
- JINNO Hideto
- Faculty of Pharmacy, Meijo University
-
- TANAKA-KAGAWA Toshiko
- Faculty of Pharmaceutical Sciences, Yokohama University of Pharmacy
Bibliographic Information
- Other Title
-
- 気道過敏性関連遺伝子のヒト気管及び肺における発現個体差
Description
<p>Significant individual differences have been noted in the degree of onset and symptoms of sick house syndrome, but the mechanism has not been elucidated. In this study, to this end, we evaluated the expression levels of ADAM33 and other genes in human tracheal and lung tissues, which are known to be involved in airway hyperreactivity and asthma. Real-time RT-PCR revealed that the gene expression level of ADAM33 did not show significant individual differences in trachea. In contrast, the levels of MMP9 and GPR99 (OXGR1) showed remarkable individual differences in trachea and lung. It is possible that these factors play an important role as one of the factors explaining individual differences in the degree of onset of sick house syndrome.</p>
Journal
-
- Annual Meeting of the Japanese Society of Toxicology
-
Annual Meeting of the Japanese Society of Toxicology 47.1 (0), P-70S-, 2020
The Japanese Society of Toxicology
- Tweet
Details 詳細情報について
-
- CRID
- 1390848647545015936
-
- NII Article ID
- 130007898452
-
- Text Lang
- ja
-
- Data Source
-
- JaLC
- CiNii Articles
-
- Abstract License Flag
- Disallowed