Novel signaling pathway related to methylmercury toxicity

DOI
  • HWANG Gi-Wook
    Graduate School of Pharmaceutical Sciences, Tohoku University Laboratory of Environmental and Health Sciences, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University

Bibliographic Information

Other Title
  • メチル水銀毒性発現に関わる新規シグナル伝達系

Abstract

<p>We recently found that oncostatin M (OSM), a kind of inflammatory cytokine, was induced from microglia in the brain of mouse treated with methylmercury. In experiments using cultured cells, extracellularly released OSM was found to be involved in enhancing methylmercury toxicity by binding to TNF receptor 3 (TNFR3). Moreover, administration of an antibody against TNFR3 directly into the mouse brain suppressed neuronal cell death caused by methylmercury. In this symposium, I will introduce the OSM/TNFR3 signaling pathway, which was suggested to function as a mechanism of methylmercury toxicity.</p>

Journal

Details 詳細情報について

  • CRID
    1390848647545156864
  • NII Article ID
    130007898482
  • DOI
    10.14869/toxpt.47.1.0_s19-5
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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