A novel <i>in vitro</i> approach for embryo-fetal risk assessment using human iPS cells

DOI

Bibliographic Information

Other Title
  • 医薬品の発生毒性リスク評価のためのヒトiPS細胞を用いた<i>in vitro</i>評価系の構築

Description

<p>In drug development, embryo-fetal risk assessment is critical to ensure safety in patients. Recently, the modality of drugs has been diversified to antibody, nucleic acids, and gene therapy; while species differences in epitopes or nucleic acid sequences limit the appropriate safety evaluations in animals. In this presentation, a convenient approach to evaluate human-specific embryo-fetal risks in vitro using human iPS cells will be introduced. Also, current in vitro systems for evaluation of embryo-fetal risk will be summarized and the usefulness of human-specific systems will be discussed.</p>

Journal

Details 詳細情報について

  • CRID
    1390848647545161088
  • NII Article ID
    130007898490
  • DOI
    10.14869/toxpt.47.1.0_s1-4
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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