Mechanism involved in the induction of OSM expression by methylmercury in microglia

DOI
  • HOSHI Takayuki
    Graduate School of Pharmaceutical Sciences, Tohoku University Department of Environmental Health, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University
  • TOYAMA Takashi
    Graduate School of Pharmaceutical Sciences, Tohoku University
  • NAGANUMA Akira
    Graduate School of Pharmaceutical Sciences, Tohoku University
  • SAITO Yoshiro
    Graduate School of Pharmaceutical Sciences, Tohoku University
  • HWANG Gi-Wook
    Graduate School of Pharmaceutical Sciences, Tohoku University Department of Environmental Health, Faculty of Pharmaceutical Sciences, Tohoku Medical and Pharmaceutical University

Bibliographic Information

Other Title
  • ミクログリアにおけるメチル水銀によるオンコスタチンM発現誘導機構

Description

<p>In this study, we aimed to elucidate the mechanism involved in the induction of oncostatin M (OSM) by methylmercury in microglia. We found that methylmercury induced OSM expression by activation of STAT3 and cJun, which are subunit of known transcription factors for OSM expression, in mouse microglial cell line BV2. Moreover, knockdown of up-stream kinases (JAK1 or ASK1/JNK) for STAT3 or cJun also attenuated methylmercury-induced OSM expression. These results suggest that methylmercury may induce OSM expression via JAK1/STAT3 and ASK1/JNK/cJun pathways in microglia.</p>

Journal

Details 詳細情報について

  • CRID
    1390848647545200512
  • NII Article ID
    130007898537
  • DOI
    10.14869/toxpt.47.1.0_p-8e
  • Text Lang
    ja
  • Data Source
    • JaLC
    • CiNii Articles
  • Abstract License Flag
    Disallowed

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