Protective Effect of <i>Thymus serpyllum</i> Extract on Glycation-Induced Epidermal Dysfunction

Kiso Akinori, Morimoto Haruka, Maeda Kazuhisa

doi:10.5107/sccj.54.264

<p>Sugars are essential nutrients for daily activities, but the glycation is known to trigger the changes to the three-dimensional structure of proteins by the induction of a lysine-arginine crosslink and to affect the activities and physical properties of proteins. In the skin, influences of aging due to glycation appear in proteins with a long half-life period, such as collagen or elastin, and glycation induces the browning reaction of skin proteins and accumulates cross-linking advanced glycation end products (AGEs), which leads to signs of skin aging such as wrinkles, a dull aspect, and the decline of firmness and elasticity. However, few studies have reported on the influence of glycosylated basement membrane on the maintenance of epidermal functions. In this study, we focused on the effect of glycation on epidermal function, and found that the production of ATP and the expressions of filaggrin (FLG), serine palmitoyltransferase 2 (SPTLC2) and transglutaminase 1 (TGM1) were decreased in keratinocytes incubated on glyceraldehyde-induced glycosylated collagen or basement membrane extract. We also found that Thymus serpyllum extract suppressed the decrease of ATP production and expressions of FLG, TGM1 and SPT, suggesting that this extract might be a promising ingredient for skin hydration and barrier repair by protecting against glycation-induced epidermal dysfunction.</p>

Protective Effect of <i>Thymus serpyllum</i> Extract on Glycation-Induced Epidermal Dysfunction

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