Structural Basis for Protein Translocation by the Translocase of the Outer Mitochondrial Membrane

DOI Web Site Web Site 1 Citations 15 References
  • ARAISO Yuhei
    Department of Clinical Laboratory Science, Division of Health Sciences, Graduate School of Medical Science, Kanazawa University

Bibliographic Information

Other Title
  • ミトコンドリアタンパク質搬入ゲートTOM複合体の立体構造
  • ミトコンドリアタンパクシツ ハンニュウ ゲート TOM フクゴウタイ ノ リッタイ コウゾウ

Search this article

Abstract

<p>The TOM complex is the main entry gate for mitochondrial proteins. Recently we determined the Cryo-EM structure of the yeast TOM complex at 3.8 Å resolution. The structure shows the dimeric form consisting of two Tom40 β-barrel channels and α-helical transmembrane subunits. The structure-based biochemical analysis revealed that presequence-containing preproteins pass through the Tom40 channel in the middle of the dimer and are transferred to the TIM23 complex. On the other hand, presequence-less preproteins leave the channel at the periphery of the TOM complex and are relayed to the chaperone proteins. Our results demonstrate the efficient transfer mechanism of preproteins.</p>

Journal

  • Seibutsu Butsuri

    Seibutsu Butsuri 60 (5), 280-283, 2020

    The Biophysical Society of Japan General Incorporated Association

Citations (1)*help

See more

References(15)*help

See more

Keywords

Details 詳細情報について

Report a problem

Back to top