マイクロ流体デバイス内の電流密度解析に基づいた経上皮電気抵抗測定用電極の設計法
書誌事項
- タイトル別名
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- Design Strategy of Electrode Patterns Based on Finite Element Analysis in Microfluidic Device for Trans-Epithelial Electrical Resistance (TEER) Measurement
- マイクロ リュウタイ デバイス ナイ ノ デンリュウ ミツド カイセキ ニ モトズイタ ケイ ジョウヒ デンキ テイコウ ソクテイヨウ デンキョク ノ セッケイホウ
- Design strategy of electrode patterns based on finite element analysis in microfluidic device for Trans‐Epithelial Electrical Resistance (TEER) measurement
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説明
<p>Trans-epithelial electrical resistance (TEER) is a widely used non-invasive and label-free measurement to evaluate the barrier function of mono-layered cells in real-time. However, TEER values depend on distribution of electric current densities generated by a combination of shapes and arrangements of plane electrodes for performing TEER, but until now, there is no systematical analysis of their effects on TEER values, causing less reproducibility. Here, we report a new strategy to design the shapes and arrangements of electrodes to perform TEER in a microfluidic device. To investigate the effects of the electrodes design on TEER values, we analyze the distribution of electric current densities using finite element method and evaluate their uniformity of sensitivity. Our strategy allowed designing several electrode patterns of electrodes combinations, capable of simultaneous cell observation with a microscope and TEER measurements.</p>
収録刊行物
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- 電気学会論文誌E(センサ・マイクロマシン部門誌)
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電気学会論文誌E(センサ・マイクロマシン部門誌) 140 (10), 285-292, 2020-10-01
一般社団法人 電気学会
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詳細情報 詳細情報について
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- CRID
- 1390848647560333056
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- NII論文ID
- 130007920655
- 210000163503
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- NII書誌ID
- AN1052634X
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- ISSN
- 13475525
- 19429541
- 13418939
- 19429533
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- NDL書誌ID
- 030688666
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- 本文言語コード
- ja
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- 資料種別
- journal article
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- データソース種別
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- JaLC
- NDLサーチ
- Crossref
- CiNii Articles
- KAKEN
- OpenAIRE
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- 抄録ライセンスフラグ
- 使用不可